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Peptide record

TPDB66037

STP Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB66037
STP
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 7-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
VATANST
Physicochemical Analysis
C26H46N8O12
RDCEQGHILKMFPWY
AT
662.70
6.02
0
0
3
-0
0.56
0.300
70.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
7
C26H46N8O12
662.70
6.02
-0
0.56
0.300
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Colon cancer
Vimentin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer
2021
Liu G et al. Front Pharmacol. 2021 Oct 15:12:744811.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
CT26
Male Kunming mice (200 g of body weight), 6–8 week-old male Balb/C mice
Synthetic
Doxorubicin, mPEG-P(Phe-co-Cys)
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Osteosarcoma
Vimentin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Application of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma
2020
Qiu R et al.Drug Deliv. 2020 Nov 28 27(1):1704-1717.

Other

143B Human osteosarcoma cells
Male BALB/c nude mice (5 weeks, 18.0–20.0 g), Female Wistar rats (6 weeks, 180.0–200.0 g)
Synthetic
Doxorubicin, mPEG-P(Phe-co-Cys)
Additional Detail Fields 3 fields
Doxorubicin, mPEG-P(Phe-co-Cys)
CT26 143B Human osteosarcoma cells
Male Kunming mice (200 g of body weight), 6–8 week-old male Balb/C mice Male BALB/c nude mice (5 weeks, 18.0–20.0 g), Female Wistar rats (6 weeks, 180.0–200.0 g)