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Peptide record

TPDB66031

GBP Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB66031
GBP
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Lipoic acid PEG amine N-terminal: Cy5.5 labeled
Sequence
THVSPNQGGLPS
Physicochemical Analysis
C50H80N16O18
ARDCEIKMFWY
GPS
1193.28
7.85
1
0
2
+0
2.79
-0.708
56.67
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
2
G
1
H
0
I
1
L
0
K
0
M
0
F
2
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C50H80N16O18
1193.28
7.85
+0
2.79
-0.708
Lipoic acid PEG amine
Cy5.5 labeled
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel
Targeting
Hepatocellular carcinoma
Glypican-3 (GPC3)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Glypican-3 (GPC3) targeted Fe(3)O(4) core/Au shell nanocomplex for fluorescence/MRI/photoacoustic imaging-guided tumor photothermal therapy
2019
Rui Tian et al. Biomater Sci. 2019 Dec 1 7(12):5258-5269.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HepG2 liver cancer cells, PC3 prostate cancer cells
Athymic nude mice (six weeks old, female, 20–24 g)
Phage display library
Fe3O4/Au core-shell nanocomplex (FANP), Cy5.5, PEG
Additional Detail Fields 3 fields
Fe3O4/Au core-shell nanocomplex (FANP), Cy5.5, PEG
HepG2 liver cancer cells, PC3 prostate cancer cells
Athymic nude mice (six weeks old, female, 20–24 g)