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Peptide record

TPDB66006

Meso-scFv-Fc Tumor-homing Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB66006
Meso-scFv-Fc
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 8-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Fc (IgG2a) N-terminal: Antihuman Meso
Sequence
SIINFEKL
Physicochemical Analysis
C45H74N10O13
ARDCQGHMPTWYV
I
963.14
6.94
1
1
4
-0
1.25
0.487
146.25
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
2
I
1
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C45H74N10O13
963.14
6.94
-0
1.25
0.487
Fc (IgG2a)
RVKR
Antihuman Meso
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Ovarian cancer
Mesothelin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted coating with antigenic peptide renders tumor cells susceptible to CD8(+) T cell-mediated killing
2012
Tae Heung Kang et al. Mol Ther. 2013 Mar 21(3):542-53.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
mesothelin-expressing ID8-meso tumor cells, tc-1/Meso tumor cells , luciferase-expressing tumor cells, E7-specific CD8+ T cells, cervical cancer cell line, HeLa
C57BL/six mice
Synthetic
Additional Detail Fields 2 fields
mesothelin-expressing ID8-meso tumor cells, tc-1/Meso tumor cells , luciferase-expressing tumor cells, E7-specific CD8+ T cells, cervical cancer cell line, HeLa
C57BL/six mice