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Peptide record

TPDB65978

D[A7R] Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB65978
D[A7R]
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 7-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
RPPLWTA
Physicochemical Analysis
C40H61N11O9
NDCEQGHIKMFSYV
P
839.99
11.05
1
0
3
+1
-0.73
-0.529
70.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
654.77
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
2
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
7
C40H61N11O9
839.99
11.05
+1
-0.73
-0.529
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Glioma
vascular endothelial growth factor receptor 2 (VEGFR2), neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Non-immunogenic, low-toxicity and effective glioma targeting MTI-31 liposomes
2019
Xiaoyi Wang et al. J Control Release. 2019 Dec 28:316:381-392.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U87 glioblastoma cell line
Male BALB/c nude mice, ICR mice of 4~6 weeks
Synthetic
MTI-31, Polyethylene glycol (PEG), DSPE (distearoylphosphatidylethanolamine)
Additional Detail Fields 3 fields
MTI-31, Polyethylene glycol (PEG), DSPE (distearoylphosphatidylethanolamine)
U87 glioblastoma cell line
Male BALB/c nude mice, ICR mice of 4~6 weeks