TPDB

3D PDB MODEL

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TPDB ID TPDB65954

Peptide_Name

RGDLATL truncated

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

RGDLATLRQLAQEDGVVGVR

FASTA

>TPDB65954|Tumor-homing Peptides|length=20
RGDLATLRQLAQEDGVVGVR

Formula C90H157N31O30

Absent Amino Acids NCHIKMFPSWY

Common Amino Acids RGLV

Mass 2153.43

PI 7.10

Basic Residues 3

Acidic Residues 3

Hydrophobic Residues 8

Net Charge +0

Boman Index 6.43

Hydrophobicity -0.265

Aliphatic Index 112.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

2

A

3

R

0

N

2

D

0

C

1

E

2

Q

3

G

0

H

0

I

3

L

0

K

0

M

0

F

0

P

0

S

1

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 2 R: 3 N: 0 D: 2 C: 0 E: 1 Q: 2 G: 3 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3

Length

20

Formula

C90H157N31O30

Mass

2153.43

PI

7.10

Net Charge

+0

Boman Index

6.43

Hydrophobicity

-0.265

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Lung cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Compositions of a peptide targeting system for treating cancer

Year 2014

Reference

US 8680045 B2

Patent US 8680045 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo SW900, H460, A549

InVivo Model Nude mice (20 g)

Source Type Phage display library

Conjugate Payload Cy5.5

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Compositions of a peptide targeting system for treating cancer

Year 2014

Reference

US 8680045 B2

Patent US 8680045 B2

Other

InVitro ExVivo MDA-MB-231, MCF-7

InVivo Model Nude mice (20 g)

Source Type Phage display library

Conjugate Payload Cy5.5

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Receptors Biomarker αvβ6

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria

Year 2022

Reference

US 11219671 B1

Patent US 11219671 B1

Other

InVivo Model Salmonella typhimurium

Source Type Phage display library

Phage Display Library Ph.D-7 Phage Display

Conjugate_Payload

Cy5.5

InVitro_ExVivo

SW900, H460, A549 MDA-MB-231, MCF-7

InVivo_Model

Nude mice (20 g) Salmonella typhimurium

Phage_Display_Library

Ph.D-7 Phage Display