Back to search

Peptide record

TPDB65952

HMC-1 Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB65952
HMC-1
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 7-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
RGDKLAK
Physicochemical Analysis
C33H62N12O10
NCEQHIMFPSTWYV
K
786.93
10.59
3
1
2
+2
3.30
-1.514
70.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C33H62N12O10
786.93
10.59
+2
3.30
-1.514
RGD, KALK mitochondria-targeting motif RGD
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
2022
Syed Faheem Askari Rizvi et al. Drug Deliv Transl Res. 2022 Jul 12(7):1774-1785.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Cy5.5-SAPD-99mTc nanoparticles
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Targeting
integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Fluorescent RGD-based pro-apoptotic peptide conjugates as mitochondria-targeting probes for enhanced anticancer activities
2020
Rizvi S et al. Biomed Pharmacother. 2020 Jul:127:110179.

Other

HeLa, U87MG, HepG2
U87MG tumor xenograft mice
Synthetic
FITC
Cyclic
Additional Detail Fields 3 fields
Cy5.5-SAPD-99mTc nanoparticles FITC
HeLa, U87MG, HepG2
U87MG tumor xenograft mice