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Peptide record

TPDB65907

PL1 Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB65907
PL1
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
PPRRGLIKLKTS
Physicochemical Analysis
C61H112N20O15
ANDCEQHMFWYV
RLKP
1365.69
12.42
4
0
3
+4
3.35
-0.817
97.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
2
K
0
M
0
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 2 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H112N20O15
1365.69
12.42
+4
3.35
-0.817
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Malignant Gliomas
Fibronectin Extra Domain B (FN-EDB), Tenascin C C-isoform (TNC-C)

Source & Reference

TumorHoPe2.0
TumorHoPe2
PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake
2021
Lingasamy P et al. Pharmaceutics. 2021 Nov 24 13(12):1998
Patent no. WO 2020/161602 A1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U87MG cell line
Mice having Glioblastoma and Prostate Carcinoma xenografts models
Phage Display Library
T7 phage library
CF555 Dye
Additional Detail Fields 4 fields
CF555 Dye
U87MG cell line
Mice having Glioblastoma and Prostate Carcinoma xenografts models
T7 phage library