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Peptide record

TPDB65895

NGR Peptide Tumor-homing Peptides standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB65895
NGR Peptide
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 3-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Methyl ester (COOCH3)
Sequence
NGR
Physicochemical Analysis
C12H23N7O5
ADCEQHILKMFPSTWYV
RNG
345.36
11.05
1
0
0
+1
1.24
-2.800
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H23N7O5
345.36
11.05
+1
1.24
-2.800
Methyl ester (COOCH3)
NGR
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Aminopeptidase N (APN/CD13)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide
2012
Yepeng Luan et al. Protein Pept Lett. 2012 Oct 19(10):1122-31.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human umbilical vein endothelial cells (HUVECs)
Balb/c athymic (nu+/nu+) mice, 5-6 weeks
Synthetic
5-Fluorouracil (5-FU), NO2
Additional Detail Fields 3 fields
5-Fluorouracil (5-FU), NO2
Human umbilical vein endothelial cells (HUVECs)
Balb/c athymic (nu+/nu+) mice, 5-6 weeks