TPDB

3D PDB MODEL

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TPDB ID TPDB65892

Peptide_Name

BRBP1

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Modification

C-terminal: Fluorescein 5-carboxytetramethylrhodamine (5-TAMRA), Cy5.5

Sequence

MYPWTEPSYLSN

FASTA

>TPDB65892|Tumor-homing Peptides|length=12
MYPWTEPSYLSN

Formula C69H94N14O21S1

Absent Amino Acids ARDCQGHIKFV

Common Amino Acids PSY

Mass 1487.65

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -1

Boman Index -0.78

Hydrophobicity -0.858

Aliphatic Index 32.50

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 8480

Absorbance 280nm 570.03

Polar Residues 6

number

0

A

0

R

1

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

1

L

0

K

1

M

0

F

2

P

2

S

1

T

1

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 2 S: 2 T: 1 W: 1 Y: 2 V: 0

Length

12

Formula

C69H94N14O21S1

Mass

1487.65

PI

3.29

Net Charge

-1

Boman Index

-0.78

Hydrophobicity

-0.858

C_terminal_Modification

Fluorescein 5-carboxytetramethylrhodamine (5-TAMRA), Cy5.5

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Target Tumor Brain Metastatic, Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Identification and characterization of a novel phage display-derived peptide with affinity for human brain metastatic breast cancer

Year 2014

Reference

Fu B et al. Biotechnol Lett.2014 Nov 36(11):2291-301

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo

Human MDA-MB-231-BR ‘‘brain-seeking’’ breast carcinoma, MDA-MB-231, MDA- MB-435S, BT-474, MCF-7 human breast carcinoma, GES-1 human gastric epithelial, HL-7702 human hepatic immortal

InVivo Model 6-week-old female BALB/c nu/nu mice

Source Type Phage Display Library

Phage Display Library M13

Conjugate Payload Fluorescein 5-carboxytetramethylrhodamine (5-TAMRA), Cy5.5

Conjugate_Payload

Fluorescein 5-carboxytetramethylrhodamine (5-TAMRA), Cy5.5

InVitro_ExVivo

Human MDA-MB-231-BR ‘‘brain-seeking’’ breast carcinoma, MDA-MB-231, MDA- MB-435S, BT-474, MCF-7 human breast carcinoma, GES-1 human gastric epithelial, HL-7702 human hepatic immortal

InVivo_Model

6-week-old female BALB/c nu/nu mice

Phage_Display_Library

M13