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Peptide record

TPDB65867

NGR Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB65867
NGR
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 5-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
KNGRE
Physicochemical Analysis
C23H42N10O9
ADCQHILMFPSTWYV
RNEGK
602.65
10.09
2
1
0
+1
4.25
-3.160
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H42N10O9
602.65
10.09
+1
4.25
-3.160
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Colon carcinoma
CD13, Integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery
2020
Tripodi A et al. Pathol Oncol Res. 2019 Dec 9 26(3):1879–1892.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
KS, HT-29, MRC-5
Orthotopic HT-29 human colon carcinoma bearing SCID mice, Subcutaneous Kaposi’s sarcoma bearing SCID mice, male BALB/c mice
Synthetic
Daunorubicin (Dau), Aminooxyacetylated (Aoa) Cathepsin B cleavable GFLG
Cyclic
Additional Detail Fields 3 fields
Daunorubicin (Dau), Aminooxyacetylated (Aoa) Cathepsin B cleavable GFLG
KS, HT-29, MRC-5
Orthotopic HT-29 human colon carcinoma bearing SCID mice, Subcutaneous Kaposi’s sarcoma bearing SCID mice, male BALB/c mice