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Peptide record

TPDB65864

tLyP-1-NLS Peptide (K12) Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB65864
tLyP-1-NLS Peptide (K12)
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
KKKRKCGNKRTR
Physicochemical Analysis
C61H119N27O15S1
ADEQHILMFPSWYV
K
1502.85
12.17
8
0
0
+8
7.71
-2.925
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H119N27O15S1
1502.85
12.17
+8
7.71
-2.925
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, parenchyma cell
Targeting
Glioma
Neuropilin-1 (NRP-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Modification of degradable nonviral delivery vehicle with a novel bifunctional peptide to enhance transfection in vivo
2018
Min Zhang et al. Nanomedicine (Lond). 2018 Jan 13(1):9-24.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U87-MG glioma cells
male Balb/c nude mice (about 20 g, 5 weeks)
Synthetic
Polyethyleneimine (PEI), N-octyl-N-quaternary chitosan (OTMCS), pING4 plasmid DNA
Additional Detail Fields 3 fields
Polyethyleneimine (PEI), N-octyl-N-quaternary chitosan (OTMCS), pING4 plasmid DNA
U87-MG glioma cells
male Balb/c nude mice (about 20 g, 5 weeks)