TPDB

3D PDB MODEL

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TPDB ID TPDB65859

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides Immunity and inflammation peptides

Database_Source

Peptipedia TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Anti-inflammatory and Tumor-homing Peptides) peptide sequence curated from Peptipedia and TumorHoPe2.0, with an available 3D structural model.

Sequence

KGHYAERVG

FASTA

>TPDB65859|Anti-inflammatory;Tumor-homing Peptides|length=9
KGHYAERVG

Formula C44H69N15O13

Absent Amino Acids NDCQILMFPSTW

Common Amino Acids G

Mass 1016.12

PI 9.74

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 3.76

Hydrophobicity -1.244

Aliphatic Index 43.33

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 146.64

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

1

E

0

Q

2

G

1

H

0

I

0

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

9

Formula

C44H69N15O13

Mass

1016.12

PI

9.74

Net Charge

+1

Boman Index

3.76

Hydrophobicity

-1.244

Chemical_Mass

1016.1086

Monoisotopic_Mass

1015.5184

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Brodsky B., Erlanger-Rosengarten A., Proscura E., Shapira E., Wormser U.

Title

From topical antidote against skin irritants to a novel counter-irritating and antiinflammatory peptide. Toxicol Appl Pharmacol., 229, 342–350, 2008

Year 2008

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)O InChI=1S/C44H69N15O13/c1-23(2)36(43(72)52-21-35(64)65)59-40(69)29(8-6-16-50-44(47)48)57-39(68)30(13-14-34(62)63)56-37(66)24(3)54-41(70)31(17-25-9-11-27(60)12-10-25)58-42(71)32(18-26-19-49-22-53-26)55-33(61)20-51-38(67)28(46)7-4-5-15-45/h9-12,19,22-24,28-32,36,60H,4-8,13-18,20-21,45-46H2,1-3H3,(H,49,53)(H,51,67)(H,52,72)(H,54,70)(H,55,61)(H,56,66)(H,57,68)(H,58,71)(H,59,69)(H,62,63)(H,64,65)(H4,47,48,50)/t24-,28-,29-,30-,31-,32-,36-/m0/s1 InChIKey=YYMGXYCTKSTFPU-HBKAQRFDSA-N

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Lung cancer, Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Peptides for the treatment of malignant proliferative diseases

Year 2020

Reference

US 10570174 B2

Patent US 10570174 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo D122 murine Lewis lung carcinoma cell line, B16-F10 Breast cancer cells

InVivo Model Female C57BL/6 mice, Female BALB/c mice (9-10 weeks old)

Source Type Synthetic

Conjugate Payload nitro group

Conjugate_Payload

nitro group

InVitro_ExVivo

D122 murine Lewis lung carcinoma cell line, B16-F10 Breast cancer cells

InVivo_Model

Female C57BL/6 mice, Female BALB/c mice (9-10 weeks old)

Number_of_Residues

9