TPDB

3D PDB MODEL

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TPDB ID TPDB65858

Peptide_Name

F3

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

KDEPQRRSARLSAKPAPPKPEPKPRKAPAKK

FASTA

>TPDB65858|Tumor-homing Peptides|length=31
KDEPQRRSARLSAKPAPPKPEPKPRKAPAKK

Formula C152H263N51O41

Absent Amino Acids NCGHIMFTWYV

Common Amino Acids P

Mass 3461.08

PI 11.59

Basic Residues 11

Acidic Residues 3

Hydrophobic Residues 6

Net Charge +8

Boman Index 18.47

Hydrophobicity -1.965

Aliphatic Index 28.71

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

5

A

4

R

0

N

1

D

0

C

2

E

1

Q

0

G

0

H

0

I

1

L

7

K

0

M

0

F

8

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 5 R: 4 N: 0 D: 1 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 7 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

31

Formula

C152H263N51O41

Mass

3461.08

PI

11.59

Net Charge

+8

Boman Index

18.47

Hydrophobicity

-1.965

Motif

(R/K)XX(R/K)

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Year 2013

Reference

Mahmoud Elsabahy et al. Nano Lett. 2013 May 8. 13(5): 2172–2181.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo OVCAR-3orRAW264.7cell line

Conjugate Payload poly(ethyleneglycol)

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Year 2012

Reference

Keiji Numata et al. Macromol Biosci. 2012 Jan 12(1):75-82.

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, endothelial cell

Homing or Targeting Homing

Target Tumor Glioma (Brain tumor)

Receptors Biomarker nucleolin, neuropilin-1 (NRP1)

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery

Year 2012

Reference

Quanyin Hu et al. Biomaterials. 2013 Jan 34(4):1135-45.

Other

InVitro ExVivo Rat C6 glioma cell line

InVivo Model Male Sprague-Dawley rats (200 20 g), Balb/c nude mice (male, 4e5 weeks, 20 2g)

Source Type Phage display

Conjugate Payload Nanoparticles (pegylated poly (trimethylene carbonate))

Conjugate_Payload

poly(ethyleneglycol) Nanoparticles (pegylated poly (trimethylene carbonate))

InVitro_ExVivo

OVCAR-3orRAW264.7cell line Rat C6 glioma cell line

InVivo_Model

Male Sprague-Dawley rats (200 20 g), Balb/c nude mice (male, 4e5 weeks, 20 2g)