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Peptide record

TPDB65857

cRGD Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB65857
cRGD
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
KCRGDPLGVRGY
Physicochemical Analysis
C56H93N19O16S1
ANEQHIMFSTW
G
1320.53
9.77
3
1
3
+2
2.65
-0.833
56.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
112.83
2
Residue Composition
number
0
A
2
R
0
N
1
D
1
C
0
E
0
Q
3
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C56H93N19O16S1
1320.53
9.77
+2
2.65
-0.833
RGD
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Metastatic lymph nodes
Targeting
Breast cancer
Integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo
2019
Ling Yin et al. J Org Chem. 2019 May 17 84(10):6126-6133.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 murine breast carcinoma cells
4-week-old female BALB/c athymic nude mice
Synthetic
Near-infrared dye (Cy5), Quencher (QSY21), Radionuclide (125I)
Cyclic
Additional Detail Fields 3 fields
Near-infrared dye (Cy5), Quencher (QSY21), Radionuclide (125I)
4T1 murine breast carcinoma cells
4-week-old female BALB/c athymic nude mice