Back to search

Peptide record

TPDB65814

MMP-2 Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB65814
MMP-2
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 11-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: PAMAM dendrimer
Sequence
GGPLGLAGGKG
Physicochemical Analysis
C38H66N12O12
RNDCEQHIMFSTWYV
G
883.02
10.10
1
0
3
+1
0.21
0.136
80.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
6
G
0
H
0
I
2
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 6 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C38H66N12O12
883.02
10.10
+1
0.21
0.136
PAMAM dendrimer
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel
Homing
Breast cancer
Neuropilin-1, Neuropilin-2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Design of a dendrimer with a matrix metalloproteinase-responsive fluorescence probe and a tumor-homing peptide for metastatic tumor cell imaging in the lymph node
2021
Nagai K et al. Bioorg Med Chem Lett. 2021 Feb 1:33:127726.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HT-1080 (human fibrosarcoma cells), 4T1 (mouse mammary tumor cells), RAW264 cells (mouse macrophage-like cells)
Synthetic
Additional Detail Fields 1 fields
HT-1080 (human fibrosarcoma cells), 4T1 (mouse mammary tumor cells), RAW264 cells (mouse macrophage-like cells)