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Peptide record

TPDB65813

BB28 Tumor-homing Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB65813
BB28
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 31-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Albumin-binding domain (WQRPSSW)
Sequence
GGLRSLGRKILRAWKKYGQRLGNQWAVGHLM-NH2
Physicochemical Analysis
C160H261N53O37S1
DCEFPT
G
3551.23
12.42
8
0
13
+7
0.69
-0.532
91.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
351.71
5
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
2
Q
6
G
1
H
1
I
5
L
3
K
1
M
0
F
0
P
1
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 6 H: 1 I: 1 L: 5 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
31
C160H261N53O37S1
3551.23
12.42
+7
0.69
-0.532
Amide
bombesin
Albumin-binding domain (WQRPSSW)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung, Breast, Colon, Prostate cancer
Gastrin-releasing peptide receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Enhancing the circulating half-life and the antitumor effects of a tumor-selective cytotoxic peptide by exploiting endogenous serum albumin as a drug carrier
2016
Tao Su et al. Int J Pharm. 2016 Feb 29 499(1-2):195-204.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
COLO 205, K562, and SMMC-7721 tumor cells
Female athymic 4–5-week-old BALB/c mice
Synthetic
ABB28 (albumin-binding domain fused to BB28), PEGylation (5K-BB28 and 10K-BB28)
Additional Detail Fields 3 fields
ABB28 (albumin-binding domain fused to BB28), PEGylation (5K-BB28 and 10K-BB28)
COLO 205, K562, and SMMC-7721 tumor cells
Female athymic 4–5-week-old BALB/c mice