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Peptide record

TPDB65810

LXY30 Tumor-homing Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB65810
LXY30
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 4-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
GFGR
Physicochemical Analysis
C19H29N7O5
ANDCEQHILKMPSTWYV
G
435.48
11.05
1
0
1
+1
-0.30
-0.625
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C19H29N7O5
435.48
11.05
+1
-0.30
-0.625
cNGXGXXc
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
non small cell Lung cancer, Glioblastoma
α3β1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors
2016
Wenwu Xiao et al. EJNMMI Res. 2016 Dec 6. 18.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models
Phage display library
Cyclic dipeptide, At 2nd position Phenylalanine (Phe) residue substituted with fluorine atoms at the 3rd and 5th positions of the benzyl ring, At 4th position hydroxyproline and norleucine group
Additional Detail Fields 2 fields
human glioblastoma U-87MG cells
orthotopic U-87MG xenograft mouse models