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Peptide record

TPDB65785

LY2510924 Tumor-homing Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB65785
LY2510924
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 8-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidated
Sequence
FYKRGDEK
Physicochemical Analysis
C47H71N13O14
ANCQHILMPSTWV
K
1042.16
9.65
3
2
2
+1
3.98
-2.275
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
142.97
1
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C47H71N13O14
1042.16
9.65
+1
3.98
-2.275
Amidated
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
SDF-1, CXCR4

Source & Reference

TumorHoPe2.0
TumorHoPe2
Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models
2015
Bin Peng S et al. Mol Cancer Ther. 2015 Feb 14(2):480-90.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231 cell line, human lymphoma U937 cells
cyclic, At 3rd position Lysine with an isopropyl modification, At 5th position 2-Naphthylalanine
Additional Detail Fields 1 fields
MDA-MB-231 cell line, human lymphoma U937 cells