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Peptide record

TPDB65777

Temporin-1Cb2 Tumor-homing Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB65777
Temporin-1Cb2
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 14-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: amide group (-NH2)
Sequence
FLFPLITSFLSKFL
Physicochemical Analysis
C87H129N15O18
ARNDCEQGHMWYV
LF
1673.07
10.10
1
0
9
+1
-5.23
1.650
139.29
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
1
K
0
M
4
F
1
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 1 M: 0 F: 4 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C87H129N15O18
1673.07
10.10
+1
-5.23
1.650
amide group (-NH2)
RGD
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Gastric cancer, Hepatocellular carcinoma, Colorectal cancer, Lung adenocarcinoma
integrin avb3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain
2012
Yuwen Diao et al. J Pept Sci. 2012 Jul 18(7):476-86.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
lung adenocarcinoma epithelial cell line(A549), human colorectal carcinomacell line(SW1116),humangastric carcinoma cell line (BGC-823), human epithelial carcinomacell line (Hela), humanhepatocellular liver carcinomacell line(HepG2), human hepato carcinoma cell line(SMMC-7721),human embryonic kidney cell line (HEK 293T), human liver cell line (HL-7702), bovine mammary epithelial cells(MECs),andperipheral blood mononuclear cell(PBMC)
Synthetic
Additional Detail Fields 1 fields
lung adenocarcinoma epithelial cell line(A549), human colorectal carcinomacell line(SW1116),humangastric carcinoma cell line (BGC-823), human epithelial carcinomacell line (Hela), humanhepatocellular liver carcinomacell line(HepG2), human hepato carcinoma cell line(SMMC-7721),human embryonic kidney cell line (HEK 293T), human liver cell line (HL-7702), bovine mammary epithelial cells(MECs),andperipheral blood mononuclear cell(PBMC)