Back to search

Peptide record

TPDB65756

P18 Tumor-homing Peptides modified_plain modified
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB65756
P18
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
modified_plain
Yes
A 11-aa modified tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
CWXEAAYQRFL
Physicochemical Analysis
C60H83N15O15S1
NDGHIKMPSTV
A
1286.47
6.28
1
1
6
-0
-1.65
-0.091
53.64
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6990
543.35
3
Residue Composition
number
2
A
1
R
0
N
0
D
1
C
1
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
11
C60H83N15O15S1
1286.47
6.28
-0
-1.65
-0.091
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
keratin-1 (KRT-1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Delivery of doxorubicin loaded P18 conjugated-poly(2-ethyl-oxazoline)-DOPE nanoliposomes for targeted therapy of breast cancer
2021
Zeynep Busra Bolat et al. Toxicol Appl Pharmacol. 2021 Oct 1:428:115671.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
AU565 breast cancer cells, breast epithelial cells (MCF10A)
athymic female CD-1 nu/nu mice (5–6 weeks of age, 20 ± 2 g)
Synthetic
PEtOx-DOPE nanoliposomes
Additional Detail Fields 3 fields
PEtOx-DOPE nanoliposomes
AU565 breast cancer cells, breast epithelial cells (MCF10A)
athymic female CD-1 nu/nu mice (5–6 weeks of age, 20 ± 2 g)