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Peptide record

TPDB65751

SHH Tumor-homing Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB65751
SHH
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 24-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
N-terminal: CVNHPAFAC
Sequence
CVNHPAFACGYGHTMYYHHYQHHL
Physicochemical Analysis
C131H172N38O32S3
RDEIKSW
H
2887.22
7.41
6
0
10
+0
0.94
-0.550
36.67
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6085
210.76
9
Residue Composition
number
2
A
0
R
1
N
0
D
2
C
0
E
1
Q
2
G
6
H
0
I
1
L
0
K
1
M
1
F
1
P
0
S
1
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 6 I: 0 L: 1 K: 0 M: 1 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 4 V: 1
Chemical Descriptors
24
C131H172N38O32S3
2887.22
7.41
+0
0.94
-0.550
CVNHPAFAC
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, tumor endothelial cell
Targeting
Glioblastoma
SHH (sonic hedgehog), VEGFR-2 (vascular endothelial growth factor receptor 2)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Multi-targeting Peptide-Functionalized Nanoparticles Recognized Vasculogenic Mimicry, Tumor Neovasculature, and Glioma Cells for Enhanced Anti-glioma Therapy
2015
Xingye F et al. ACS Appl Mater Interfaces. 2015 Nov 7(46):25723-35.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
UVEC cells and U87MG cells.
Glioma-bearing nude mice with DiR-loaded nanoparticles​
Synthetic
PEG-PLA
Additional Detail Fields 3 fields
PEG-PLA
UVEC cells and U87MG cells.
Glioma-bearing nude mice with DiR-loaded nanoparticles​