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Peptide record

TPDB65714

iRGD Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB65714
iRGD
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 11-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Fluorescence quencher, dabcyl (4-((4-(dimethylamino)phenyl)azo)benzoic acid) N-terminal: iRGD with FAM
Sequence
CRGDKRGPDEC
Physicochemical Analysis
C46H78N18O18S2
ANQHILMFSTWYV
RDCG
1235.36
6.27
3
3
0
-0
7.08
-1.891
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
10.12
2
Residue Composition
number
0
A
2
R
0
N
2
D
2
C
1
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 2 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C46H78N18O18S2
1235.36
6.27
-0
7.08
-1.891
Fluorescence quencher, dabcyl (4-((4-(dimethylamino)phenyl)azo)benzoic acid)
iRGD with FAM
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Targeting
Breast cancer
Alpha-5, Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity
2014
Pang HB et al. J Control Release. 2014 Feb 10:175:48-53.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Wild type (WT) Balb/c mice BALB/c nude mice, injected with 4T1 mouse breast cancer cell
Synthetic
C-GGS-H6 with fluorescein (FAM)
Additional Detail Fields 2 fields
C-GGS-H6 with fluorescein (FAM)
Wild type (WT) Balb/c mice BALB/c nude mice, injected with 4T1 mouse breast cancer cell