TPDB

3D PDB MODEL

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TPDB ID TPDB65711

Peptide_Name

iRGDD

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

CRGDDGPDC

FASTA

>TPDB65711|Tumor-homing Peptides|length=9
CRGDDGPDC

Formula C33H52N12O16S2

Absent Amino Acids ANEQHILKMFSTWYV

Common Amino Acids D

Mass 936.97

PI 3.59

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 0

Net Charge -2

Boman Index 4.49

Hydrophobicity -1.378

Aliphatic Index 0.00

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 13.34

Polar Residues 2

number

0

A

1

R

0

N

3

D

2

C

0

E

0

Q

2

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 3 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C33H52N12O16S2

Mass

936.97

PI

3.59

Net Charge

-2

Boman Index

4.49

Hydrophobicity

-1.378

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell

Homing or Targeting Homing

Target Tumor Lung cancer, Breast cancer, Liver cancer, Melanoma, Pancreatic cancer, Colorectal cancer, Prostate cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Methods and compositions using peptides and proteins with C-terminal elements

Year 2019

Reference

US 10370245 B2

Patent US 10370245 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line

InVivo Model BALB/c athymic nude mice

Source Type Phage Display library

Phage Display Library T7 phage display library

Conjugate Payload nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]

Conjugate_Payload

nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]

InVitro_ExVivo

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line

InVivo_Model

BALB/c athymic nude mice

Phage_Display_Library

T7 phage display library