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Peptide record

TPDB65704

CF Tumor-homing Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB65704
CF
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 37-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CREKACKDEPQRRSARLSAKPAPPKPEPKPKKAPAKK-NH2
Physicochemical Analysis
C178H309N59O49S2
NGHIMFTWYV
K
4123.90
10.80
13
4
7
+9
21.82
-1.768
26.76
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
3.03
5
Residue Composition
number
6
A
4
R
0
N
1
D
2
C
3
E
1
Q
0
G
0
H
0
I
1
L
9
K
0
M
0
F
8
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 4 N: 0 D: 1 C: 2 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 9 M: 0 F: 0 P: 8 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
37
C178H309N59O49S2
4123.90
10.80
+9
21.82
-1.768
Amidation
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing
Breast cancer
Epithelial Cell

Source & Reference

TumorHoPe2.0
TumorHoPe2
pH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer
2019
Wan Xu et al. Drug Deliv. 2019 Dec 26(1):470-480

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231
Orthotropic breast cancers bearing female nude Balb/c mice
Synthetic
Erlotinib (EB), (GSI)-DAPT
CN2 chemical spacer between CREKA and F3 peptide
Additional Detail Fields 3 fields
Erlotinib (EB), (GSI)-DAPT
MDA-MB-231
Orthotropic breast cancers bearing female nude Balb/c mice