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Peptide record

TPDB65700

CRALK Tumor-homing Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB65700
CRALK
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 20-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation
Sequence
CRALKYSHSHSYWLRSGGGC-NH2
Physicochemical Analysis
C98H146N32O27S2
NDEQIMFPTV
S
2268.56
9.62
5
0
6
+3
-0.42
-0.640
44.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8605
379.32
8
Residue Composition
number
1
A
2
R
0
N
0
D
2
C
0
E
0
Q
3
G
2
H
0
I
2
L
1
K
0
M
0
F
0
P
4
S
0
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 3 H: 2 I: 0 L: 2 K: 1 M: 0 F: 0 P: 0 S: 4 T: 0 W: 1 Y: 2 V: 0
Chemical Descriptors
20
C98H146N32O27S2
2268.56
9.62
+3
-0.42
-0.640
Amidation
Biotinylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell and tumor vasculature
Homing
Neuroblastoma
NRP-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Enhancement of Tumor Homing by Chemotherapy-Loaded Nanoparticles
2018
Ponzoni M et al. Small. 2018 Nov 14(45):e1802886.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
IMR-32, HTLA-230, SH-SY5Y, and LAN-5
4-week-old female athymic Nude-Foxn1nu mice, 5-week-old female athymic Nude-Foxn1nu mice
Synthetic
Doxorubicin, FITC
Additional Detail Fields 3 fields
Doxorubicin, FITC
IMR-32, HTLA-230, SH-SY5Y, and LAN-5
4-week-old female athymic Nude-Foxn1nu mice, 5-week-old female athymic Nude-Foxn1nu mice