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Peptide record

TPDB65686

NLN Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB65686
NLN
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 9-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
N-terminal: Biotinylation
Sequence
CNLNTIDTC
Physicochemical Analysis
C38H65N11O16S2
AREQGHKMFPSWYV
NCT
996.12
3.10
0
1
2
-1
1.00
0.156
86.67
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.55
6
Residue Composition
number
0
A
0
R
2
N
1
D
2
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C38H65N11O16S2
996.12
3.10
-1
1.00
0.156
Biotinylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
tumor metastasis
CD44v6

Source & Reference

TumorHoPe2.0
TumorHoPe2
Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice
2021
Khan F et al. Theranostics. 2021 Jan 1 11(3):1326-1344.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HEK 293T, MDA-MB231, MCF-7, 4T1, Panc-1
6-week-old female BALB/c nude mouse
Phage display library
T7 phage / CX7C peptide library
FITC, TAMRA, Flamma 675 near-infrared (NIR) fluorescence dye
Additional Detail Fields 4 fields
FITC, TAMRA, Flamma 675 near-infrared (NIR) fluorescence dye
HEK 293T, MDA-MB231, MCF-7, 4T1, Panc-1
6-week-old female BALB/c nude mouse
T7 phage / CX7C peptide library