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Peptide record

TPDB65662

TT1 Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB65662
TT1
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 9-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
CKRGARSTC
Physicochemical Analysis
C36H68N16O12S2
NDEQHILMFPWYV
RC
981.16
10.12
3
0
1
+3
2.24
-0.889
11.11
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.74
4
Residue Composition
number
1
A
2
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C36H68N16O12S2
981.16
10.12
+3
2.24
-0.889
Evidence Records 3 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
Breast cancer
P32

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

MCF10-CA1a breast cancer cell line
Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
D(KLAKLAK)2, Nanoworms(NWs), polyethylene glycol
Both Linear and cyclic
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor macrophage, Tumor cell, Endothelial cell
Homing
Breast cancer
Cell surface p32

Source & Reference

TumorHoPe2.0
TumorHoPe2
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
2016
Lauri Paasonen et al. Chembiochem. 2016 Apr 1 17(7):570-5.

Other

MCF10Ca1A breast Cancer cell line
Phage Display Library
T7 phage CX7C peptide library
Additional Detail Fields 4 fields
Nanoworms(NWs), polyethylene glycol D(KLAKLAK)2, Nanoworms(NWs), polyethylene glycol
MCF10-CA1a breast cancer cell line MCF10Ca1A breast Cancer cell line
Athymic nude mice, ApoE null mice
T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage CX7C peptide library