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Peptide record

TPDB65657

tLyP-1-NLS (K14) Peptide Tumor-homing Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB65657
tLyP-1-NLS (K14) Peptide
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 14-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Cysteine N-terminal: Cysteine
Sequence
CKKKRKCGNKRTRC
Physicochemical Analysis
C67H129N29O17S3
ADEQHILMFPSWYV
K
1709.13
11.06
8
0
0
+8
7.23
-2.150
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
7.31
5
Residue Composition
number
0
A
3
R
1
N
0
D
3
C
0
E
0
Q
1
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 3 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C67H129N29O17S3
1709.13
11.06
+8
7.23
-2.150
Cysteine
tLyP-1 (CGNKRTR), NLS (KKKRK)
Cysteine
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Ovarian cancer
Neuropilin receptors

Source & Reference

TumorHoPe2.0
TumorHoPe2
A Co-Delivery System of Curcumin and p53 for Enhancing the Sensitivity of Drug-Resistant Ovarian Cancer Cells to Cisplatin
2020
Xinli Guo et al. Molecules. 2020 Jun 4. 25(11):2621.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
SKOV3-DDP ovarian cancer cells
Synthetic
Polyethyleneimine (PEI), Curcumin (CUR), p53 DNA
Additional Detail Fields 2 fields
Polyethyleneimine (PEI), Curcumin (CUR), p53 DNA
SKOV3-DDP ovarian cancer cells