TPDB

3D PDB MODEL

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TPDB ID TPDB65646

Peptide_Name

CooP-CPP-Cbl

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 34-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Modification

C-terminal: MBHA (4-methylbenzhydrylamine-polystyrene) N-terminal: Isothiocyanate activated fluorescein (FITC)

Sequence

CGLSGLGVAGGMVRRFLVTLRIRRACGPPRVRVK

FASTA

>TPDB65646|Tumor-homing Peptides|length=34
CGLSGLGVAGGMVRRFLVTLRIRRACGPPRVRVK

Formula C158H280N56O37S3

Absent Amino Acids NDEQHWY

Common Amino Acids R

Mass 3652.49

PI 12.53

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +8

Boman Index 3.51

Hydrophobicity 0.338

Aliphatic Index 105.88

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.42

Polar Residues 4

number

2

A

7

R

0

N

0

D

2

C

0

E

0

Q

6

G

0

H

1

I

4

L

1

K

1

M

1

F

2

P

1

S

1

T

0

W

0

Y

5

V

Amino Acid Distribution

A: 2 R: 7 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 1 L: 4 K: 1 M: 1 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 5

Length

34

Formula

C158H280N56O37S3

Mass

3652.49

PI

12.53

Net Charge

+8

Boman Index

3.51

Hydrophobicity

0.338

C_terminal_Modification

MBHA (4-methylbenzhydrylamine-polystyrene)

N_terminal_Modification

Isothiocyanate activated fluorescein (FITC)

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel, Invasive tumor satellite

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Novel target for peptide-based imaging and treatment of brain tumors

Year 2014

Reference

Hyvönen M et al. Mol Cancer Ther.2014 Apr 13(4):996-1007

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo U87MG human, BT4C rat glioma cells

InVivo Model 4-6 weeks old athymic female Balb/c nu-nu mice

Source Type Phage Display Library

Phage Display Library T7 phage / CX7C peptide library

Conjugate Payload Isothiocyanate activated fluorescein (FITC) at N-terminus, MBHA (4-methylbenzhydrylamine-polystyrene) at C-terminus

Conjugate_Payload

Isothiocyanate activated fluorescein (FITC) at N-terminus, MBHA (4-methylbenzhydrylamine-polystyrene) at C-terminus

InVitro_ExVivo

U87MG human, BT4C rat glioma cells

InVivo_Model

4-6 weeks old athymic female Balb/c nu-nu mice

Phage_Display_Library

T7 phage / CX7C peptide library