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Peptide record

TPDB65641

Iso1 Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB65641
Iso1
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 6-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
CGDGRG
Physicochemical Analysis
C19H33N9O9S1
ANEQHILKMFPSTWYV
G
563.59
6.09
1
1
0
-0
1.83
-1.117
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
1
D
1
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C19H33N9O9S1
563.59
6.09
-0
1.83
-1.117
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Endothelial cell, macrophage, lymphocyte, dendritic cell
Homing
Fibrosarcoma, Mammary adenocarcinoma, Prostate adenocarcinoma
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold
2019
Anna Maria Gasparri et al. Small. 2019 Nov 15(45):e1903462.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Murine WEHI-164 fibrosarcoma mammary adenocarcinoma (TS/A) cells
Heterozygous CD45.2+ C57BL/6 TRAMP mice, wild-type CD45.1+ congenic mice
Synthetic
Gold nanoparticles (Au), Interleukin-12 (IL12), Human serum albumin (HSA)
Additional Detail Fields 3 fields
Gold nanoparticles (Au), Interleukin-12 (IL12), Human serum albumin (HSA)
Murine WEHI-164 fibrosarcoma mammary adenocarcinoma (TS/A) cells
Heterozygous CD45.2+ C57BL/6 TRAMP mice, wild-type CD45.1+ congenic mice