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Peptide record

TPDB65633

nRGD Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB65633
nRGD
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 13-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Cysteine
Sequence
CCRGDKNAAGPDC
Physicochemical Analysis
C48H80N18O19S3
EQHILMFSTWYV
C
1309.45
6.01
2
2
2
-0
4.09
-0.785
15.38
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
9.55
4
Residue Composition
number
2
A
1
R
1
N
2
D
3
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 3 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C48H80N18O19S3
1309.45
6.01
-0
4.09
-0.785
Cysteine
Alanine-alanine-asparagine(AAN)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell
Homing
Breast cancer
Alpha-5 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment
2016
Song X et al. Biomaterials. 2016 Nov:108:44-56

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
RAW 264.7 (Murine Macrophage), HUVEC (Human Umbilical Vein Endothelial cells), 4T1 (Murine Breast Cancer cells) cells
6-8 weeks Female BALB/c mice bearing 4T1 tumors
Synthetic
Fluorescein isothiocyanate (FITC) , Doxorubicin(DOX)
Additional Detail Fields 3 fields
Fluorescein isothiocyanate (FITC) , Doxorubicin(DOX)
RAW 264.7 (Murine Macrophage), HUVEC (Human Umbilical Vein Endothelial cells), 4T1 (Murine Breast Cancer cells) cells
6-8 weeks Female BALB/c mice bearing 4T1 tumors