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Peptide record

TPDB65615

Tumor-homing Peptides modified_plain modified
8 amino acids
Basic Information
3D PDB MODEL
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TPDB65615
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
modified_plain
Yes
A 8-aa modified tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
N-terminal: Cu2+ and Ni2+ binding
Sequence
ATCUNVVH
Physicochemical Analysis
C30H50N10O10S1
RDEQGILKMFPSWY
V
742.85
7.15
1
0
3
+0
1.25
0.662
85.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
8
C30H50N10O10S1
742.85
7.15
+0
1.25
0.662
ATCUN
Cu2+ and Ni2+ binding
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
somatostatin receptor 2 (SSTR2)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Enhanced stability of Cu(2+)-ATCUN complexes under physiologically relevant conditions by insertion of structurally bulky and hydrophobic amino acid residues into the ATCUN motif
2016
Takaaki Miyamoto et al. Dalton Trans. 2016 May 17. 45, 9436-9445

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
9 weeks old Female BALB/c nude mice
Synthetic
octreotide
Additional Detail Fields 2 fields
octreotide
9 weeks old Female BALB/c nude mice