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Peptide record

TPDB65609

Thx Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB65609
Thx
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 7-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Fmoc-11-amino 3,6,9-undecanoic acid, 2-aminoethanethiol linker
Sequence
ARRPKLD
Physicochemical Analysis
C36H66N14O10
NCEQGHIMFSTWYV
R
855.01
11.32
3
1
2
+2
3.56
-1.771
70.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
2
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C36H66N14O10
855.01
11.32
+2
3.56
-1.771
Fmoc-11-amino 3,6,9-undecanoic acid, 2-aminoethanethiol linker
[A/S]RXPXXX
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

NSCLC cell (NCI-H23, NCI-H520, NCI-460, A549, PAMSC,NIH-3T3)
Homing
Non-small cell Lung cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
A novel peptide (Thx) homing to non-small cell lung cancer identified by ex vivo phage display
2012
A Koivistoinen et al. Clin Transl Oncol. 2013 Jun 15(6):492-8.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
NSCLC cell line NCI-H23, NCI-H520, and NCI-460
athymic-nu nude mice
Synthetic
X7phage/X11 phage/ M13 phage/ fUSE5 phage peptide libraries
DTPA-Europium, Alexa488
Additional Detail Fields 4 fields
DTPA-Europium, Alexa488
NSCLC cell line NCI-H23, NCI-H520, and NCI-460
athymic-nu nude mice
X7phage/X11 phage/ M13 phage/ fUSE5 phage peptide libraries