TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB65607

Peptide_Name

AR

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

AREYGTRFSLIGGYR

FASTA

>TPDB65607|Tumor-homing Peptides|length=15
AREYGTRFSLIGGYR

Formula C78H120N24O22

Absent Amino Acids NDCQHKMPWV

Common Amino Acids RG

Mass 1745.96

PI 10.24

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +2

Boman Index 0.70

Hydrophobicity -0.627

Aliphatic Index 58.67

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 170.68

Polar Residues 4

number

1

A

3

R

0

N

0

D

0

C

1

E

0

Q

3

G

0

H

1

I

1

L

0

K

0

M

1

F

0

P

1

S

1

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 0

Length

15

Formula

C78H120N24O22

Mass

1745.96

PI

10.24

Net Charge

+2

Boman Index

0.70

Hydrophobicity

-0.627

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell, Tumor cell, Tumor vessel

Homing or Targeting Homing

Target Tumor Breast cancer

Receptors Biomarker CD31

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Anti-angiogenin peptides, compositions, and methods of use

Year 2023

Reference

US 11839642 B2

Patent US 11839642 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo MCF-7 breast cancer cell line

InVivo Model 4-week-old athymic nude mouse

Source Type Phage display library

Phage Display Library Ph.D.-12 phage-displayed random peptide library

Conjugate Payload nanofibers, nano-cages, nano-dendrites

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Breast cancer

Receptors Biomarker -MCF 7.00

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Metal-Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor-Targeting Peptides for Targeted Multimodal Cancer Therapy

Year 2023

Reference

Chen Y et al. Adv Sci (Weinh). 2023 Oct 10(28):e2302700.

Other

InVitro ExVivo Seeded MCF-7 cells

InVivo Model Female athymic BALB/c nude mice

Source Type Synthetic

Conjugate Payload PEI coating, EDC, NHS

Conjugate_Payload

nanofibers, nano-cages, nano-dendrites PEI coating, EDC, NHS

InVitro_ExVivo

MCF-7 breast cancer cell line Seeded MCF-7 cells

InVivo_Model

4-week-old athymic nude mouse Female athymic BALB/c nude mice

Phage_Display_Library

Ph.D.-12 phage-displayed random peptide library