TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB65596

Peptide_Name

A54

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

AGKGTPSLETTP

FASTA

>TPDB65596|Tumor-homing Peptides|length=12
AGKGTPSLETTP

Formula C49H83N13O19

Absent Amino Acids RNDCQHIMFWYV

Common Amino Acids T

Mass 1158.27

PI 6.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index 3.75

Hydrophobicity -0.725

Aliphatic Index 40.83

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

2

G

0

H

0

I

1

L

1

K

0

M

0

F

2

P

1

S

3

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 3 W: 0 Y: 0 V: 0

Length

12

Formula

C49H83N13O19

Mass

1158.27

PI

6.94

Net Charge

-0

Boman Index

3.75

Hydrophobicity

-0.725

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Hepatocellular carcinoma

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Multifunctional SPIO/DOX-loaded A54 Homing Peptide Functionalized Dextran-g-PLGA Micelles for Tumor Therapy and MR Imaging

Year 2016

Reference

Jun-Qing Situ et al. Sci Rep. 2016 Oct 24:6:35910.

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo BEL-7402 hepatoma carcinoma cell line

InVivo Model BALB/C + nu/F1 nude mice about 6–8 weeks old

Source Type Phage Display library

Conjugate Payload DOX (Doxorubicin), SPIO (Superparamagnetic Iron Oxide nanoparticles)

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Specific targeting of A54 homing peptide-functionalized dextran-g-poly(lactic-co-glycolic acid) micelles to tumor cells

Year 2015

Reference

Jun-Qing Situ et al. Int J Nanomedicine. 2015 Jan 17:10:665-75

Other

InVitro ExVivo BEL-7402 cell line and HepG2 cell line

InVivo Model BALB/C + nu/F1 nude mice

Source Type Phage Display Library

Conjugate Payload dextran-g-poly(lactic-co-glycolic acid) micelles

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Homing

Target Tumor Liver cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title

Micelles modified with a chitosan-derived homing peptide for targeted intracellular delivery of ginsenoside compound K to liver cancer cells

Year 2020

Reference

Zhang J et al. Carbohydr Polym.2020 Feb 15:230:115576

Other

InVitro ExVivo HepG2, Huh-7 cell

Source Type Phage Display Library

Conjugate Payload APD-CK micelles

Conjugate_Payload

DOX (Doxorubicin), SPIO (Superparamagnetic Iron Oxide nanoparticles) dextran-g-poly(lactic-co-glycolic acid) micelles APD-CK micelles

InVitro_ExVivo

BEL-7402 hepatoma carcinoma cell line BEL-7402 cell line and HepG2 cell line HepG2, Huh-7 cell

InVivo_Model

BALB/C + nu/F1 nude mice about 6–8 weeks old BALB/C + nu/F1 nude mice