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Peptide record

TPDB65571

Tumor-homing Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB65571
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 11-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
ACDCRGDCFCG
Physicochemical Analysis
C42H64N14O16S4
NEQHILKMPSTWYV
C
1149.29
3.88
1
2
2
-1
1.03
0.209
9.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
250
21.75
4
Residue Composition
number
1
A
1
R
0
N
2
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 2 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C42H64N14O16S4
1149.29
3.88
-1
1.03
0.209
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor vasculature
Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
Breast cancer
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy
2016
Seung-Hwan Park et al. Theranostics. 2016 Jun 20 6(10):1672-82.

Other

MDA-MB-231 (human breast cancer), MDA-MB-435 (human melanoma), U87MG (human glioblastoma), MCF7 (human breast cancer), ASPC-1 (human pancreatic cancer), CT-26 (mouse colon carcinoma), and 4T1 (mouse breast cancer) cell line
Five- to six-week-old male nude (nu-/nu-) and C57BL/6 mice (20-25 g)
radiolabeled
Additional Detail Fields 4 fields
radiolabeled
MDA-MB-231 (human breast cancer), MDA-MB-435 (human melanoma), U87MG (human glioblastoma), MCF7 (human breast cancer), ASPC-1 (human pancreatic cancer), CT-26 (mouse colon carcinoma), and 4T1 (mouse breast cancer) cell line
Salmonella typhimurium Five- to six-week-old male nude (nu-/nu-) and C57BL/6 mice (20-25 g)
Ph.D-7 Phage Display