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Peptide record

TPDB64997

Tyr-Melanocyte-stimu Blood-Brain Barrier standard

4 amino acids

3D PDB MODEL

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TPDB ID TPDB64997

Peptide_Name

Tyr-Melanocyte-stimu

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

YPLG

FASTA

>TPDB64997|Blood-Brain Barrier|length=4
YPLG

Formula C22H32N4O6

Absent Amino Acids ARNDCEQHIKMFSTWV

Common Amino Acids GLPY

Mass 448.52

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.04

Hydrophobicity 0.125

Aliphatic Index 97.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 332.20

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C22H32N4O6

Mass

448.52

5.94

Net Charge

-0

Boman Index

-1.04

Hydrophobicity

0.125

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Pro-Leu-Gly

SMILES

O=C(NC(C(=O)NCC(=O)O)CC(C)C)C2N(C(=O)C(N)Cc1ccc(O)cc1)CCC2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00146 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional flux rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Saturable

Label H3/C14

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.036 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution vaolume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Saturable

Label H3/C14

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 87.25%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label H3/C14

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 12.75%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label H3/C14

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.064 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.48

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.12

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label H3/C14

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00008207 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Transport Type Permeability

Evidence 9 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0000820667 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Transport Type Permeability

Evidence 10 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00226 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectonal influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

In Vivo Mode of Delivery In situ perfusion (single time)

Transport Type Permeability

Label H3/C14

In_Vivo_Mode_of_Delivery

in situ brain perfusion In situ perfusion (single time)