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Peptide record

TPDB64994

Nesfatin-1 Blood-Brain Barrier standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB64994
Nesfatin-1
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
standard
No
A 82-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDEL
Physicochemical Analysis
C424H684N116O136
CMW
E
9582.79
4.67
15
19
29
-7
41.00
-0.711
100.85
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
4470
46.65
15
Residue Composition
number
2
A
6
R
1
N
8
D
0
C
11
E
3
Q
2
G
3
H
5
I
9
L
6
K
0
M
1
F
5
P
4
S
4
T
0
W
3
Y
9
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 8 C: 0 E: 11 Q: 3 G: 2 H: 3 I: 5 L: 9 K: 6 M: 0 F: 1 P: 5 S: 4 T: 4 W: 0 Y: 3 V: 9
Chemical Descriptors
82
C424H684N116O136
9582.79
4.67
-7
41.00
-0.711
Linear
Similarity
Val-Pro-Ile-Asp-Val-Asp-Lys-Thr-Lys-Val-His-Asn-Val-Glu-Pro-Val-Glu-Ser-Ala-Arg-Ile-Glu-Pro-Pro-Asp-Thr-Gly-Leu-Tyr-Tyr-Asp-Glu-Tyr-Leu-Lys-Gln-Val-Ile-Glu-Val-Leu-Glu-Thr-Asp-Pro-His-Phe-Arg-Glu-Lys-Leu-Gln-Lys-Ala-Asp-Ile-Glu-Glu-Ile-Arg-Ser-Gly-Arg-Leu-Ser-Gln-Glu-Leu-Asp-Leu-Val-Ser-His-Lys-Val-Arg-Thr-Arg-Leu-Asp-Glu-Leu
[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CCC(O)
Evidence Records 14 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
35.95 %/g

Assay & Model

Efflux study ICU
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
28.6 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

non saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
23.8 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

non saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.0003049 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

in situ brain perfusion
non saturable
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.00051 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.00105 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (brain/serum)

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
-2.07

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
0.0002 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Intravenous
Permeability
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
0.00979 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Intravenous
non saturable
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
9.46 min

Assay & Model

Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

Intravenous
non saturable
Direct iodination
Evidence 11 Activity

Activity

Blood-Brain Barrier
0.0012 ml/g

Assay & Model

Origin/Source
CD (capillary/serum)

Source & Reference

NA
B3Pdb

Other

Intravenous
Permeability
Direct iodination
Evidence 12 Activity

Activity

Blood-Brain Barrier
0.00598 ml/g

Assay & Model

Origin/Source
CD (brain/serum)

Source & Reference

NA
B3Pdb

Other

Intravenous
Permeability
Direct iodination
Evidence 13 Activity

Activity

Blood-Brain Barrier
0.01422 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Intravenous
Permeability
Direct iodination
Evidence 14 Activity

Activity

Blood-Brain Barrier
0.00011 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Intravenous
non saturable
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion Intravenous