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Peptide record

TPDB64988

des-Tyrosine1-D-Phen Blood-Brain Barrier standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB64988
des-Tyrosine1-D-Phen
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
standard
No
A 4-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
PFPG
Physicochemical Analysis
C21H28N4O5
ARNDCEQHILKMSTWYV
P
416.48
6.02
0
0
1
-0
-0.22
-0.200
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C21H28N4O5
416.48
6.02
-0
-0.22
-0.200
Linear
Similarity
Pro-D-Phe-Pro-Gly
N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
18 (x 10-4) cm/min

Assay & Model

Initial concentration in donor chamber-Culture
Origin/Source
Permeability index

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
H3/C14