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Peptide record

TPDB64986

Epidermal growth fac Blood-Brain Barrier standard
53 amino acids
Basic Information
3D PDB MODEL
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TPDB64986
Epidermal growth fac
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
standard
No
A 53-aa standard natural blood-brain barrier peptide sequence curated from Peptipedia, with an available 3D structural model.
Chemical: Cys6-Cys20, Cys14-Cys31, Cys33-Cys42
Sequence
NSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELR
Physicochemical Analysis
C270H401N73O83S7
FT
C
6222.01
4.58
7
9
20
-4
9.24
-0.425
71.70
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
18825
302.55
17
Residue Composition
number
2
A
3
R
2
N
5
D
6
C
4
E
1
Q
4
G
2
H
2
I
5
L
2
K
1
M
0
F
1
P
3
S
0
T
2
W
5
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 5 C: 6 E: 4 Q: 1 G: 4 H: 2 I: 2 L: 5 K: 2 M: 1 F: 0 P: 1 S: 3 T: 0 W: 2 Y: 5 V: 3
Chemical Descriptors
53
C270H401N73O83S7
6222.01
4.58
-4
9.24
-0.425
Cys6-Cys20, Cys14-Cys31, Cys33-Cys42
Linear
Similarity
Asn-Ser-Asp-Ser-Glu-Cys-Pro-Leu-Ser-His-Asp-Gly-Tyr-Cys-Leu-His-Asp-Gly-Val-Cys-Met-Tyr-Ile-Glu-Ala-Leu-Asp-Lys-Tyr-Ala-Cys-Asn-Cys-Val-Val-Gly-Tyr-Ile-Gly-Glu-Arg-Cys-Gln-Tyr-Arg-Asp-Leu-Lys-Trp-Trp-Glu-Leu-Arg
[H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C
Evidence Records 6 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
34 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

human,synthetic
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.02 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

human,synthetic
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.0121 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (parenchyma/serum)

Source & Reference

NA
B3Pdb

Other

human,synthetic
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.00684 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

human,synthetic
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
-1.37

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

human,synthetic
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.00202 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

human,synthetic
Intravenous
Saturable
Direct iodination
Additional Detail Fields 1 fields
Intravenous