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Peptide record

TPDB64947

cRGD-Exo Blood-Brain Barrier Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB64947
cRGD-Exo
Blood-Brain Barrier Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Blood-Brain Barrier and Tumor-homing Peptides) peptide sequence curated from BBPpredict and TumorHoPe2.0, with an available 3D structural model.
Sequence
RGDYK
Physicochemical Analysis
C27H43N9O9
ANCEQHILMFPSTWV
RDGKY
637.69
9.74
2
1
1
+1
2.10
-2.720
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
233.65
1
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C27H43N9O9
637.69
9.74
+1
2.10
-2.720
Linear
RGD
Similarity
Arg-Gly-Asp-D-Tyr-Lys
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

MCAO mice model
Origin/Source

Source & Reference

NA
B3Pdb
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
αVβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin
2018
Wenjun Shan et al. Nanomedicine. 2018 Apr 14(3):725-734.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
U87MG human glioblastoma cells, B16F10 murine melanoma cells
BALB/c nude mice
Synthetic
lipophilic NS5A peptide, 6xHis tag, Doxorubicin (DOX), HBc virus-like particles (VLPs)
Cyclic
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Glioblastoma
Integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide
2017
Shan-Shan Xue et al. Chem Commun (Camb). 2017 Jan 10 53(5):842-845.

Other

U87MG human glioblastoma cell, human breast cancer (MCF-7), human lung adenocarcinoma epithelial (A549), cisplatin-resistant A549 (A549R) and human normal liver (LO2) cells
Synthetic
Ruthenium polypyridyl complex (Ru-CD), β-cyclodextrin (β-CD), adamantane (Ad)
Cyclic
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Colon cancer
Integrin αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo
2018
Teng Ma et al. Nanoscale. 2018 Jul 19 10(28):13462-13470.

Other

4T1 cells, HCT116 cells
4-week-old female BALB/c nude mice
nanoprobe AzHD-LP (encapsulated in liposome,LP)
Cyclic
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Glioblastoma
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Gd and Eu Co-Doped Nanoscale Metal-Organic Framework as a T(1)-T(2) Dual-Modal Contrast Agent for Magnetic Resonance Imaging
2016
Geoffrey D.Wang et al. Tomography. 2016 Sep 2. (3)179-187

Other

U87MG (human glioblastoma) cells
Six-week-old female BALB/c mice, 6-week-old nude mice
Synthetic
Cyclic
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis
2013
Markus Nahrwold et al. J Med Chem. 2013 Mar 14 56(5):1853-64.

Other

cervix carcinoma cell line KB-3-1
Synthetic
cryptophycin-52
Cyclic
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Homing
Squamous carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
2016
Yanzuo Chen et al. PLoS One. 2016 Mar 1 11(3):e0149952.

Other

Doxorubicin, Paclitaxel
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Targeting
Alpha-5 beta -3 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma
2019
Chai Z et al. ACS Nano. 2019 May 28 13(5):5591-5601

Other

U87 cells, Human Umbilical Vascular Endothelial cells (HUVECs)
Healthy nude male mice
Synthetic
Mal-PEG3500-biotin
Cyclic
Additional Detail Fields 3 fields
lipophilic NS5A peptide, 6xHis tag, Doxorubicin (DOX), HBc virus-like particles (VLPs) Ruthenium polypyridyl complex (Ru-CD), β-cyclodextrin (β-CD), adamantane (Ad) nanoprobe AzHD-LP (encapsulated in liposome,LP) cryptophycin-52 Doxorubicin, Paclitaxel Mal-PEG3500-biotin
U87MG human glioblastoma cells, B16F10 murine melanoma cells U87MG human glioblastoma cell, human breast cancer (MCF-7), human lung adenocarcinoma epithelial (A549), cisplatin-resistant A549 (A549R) and human normal liver (LO2) cells 4T1 cells, HCT116 cells U87MG (human glioblastoma) cells cervix carcinoma cell line KB-3-1 U87 cells, Human Umbilical Vascular Endothelial cells (HUVECs)
BALB/c nude mice 4-week-old female BALB/c nude mice Six-week-old female BALB/c mice, 6-week-old nude mice Healthy nude male mice