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Peptide record

TPDB64938

MVIIA-d Blood-Brain Barrier standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB64938
MVIIA-d
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
BBPpredict
standard
No
A 39-aa standard natural blood-brain barrier peptide sequence curated from BBPpredict, with an available 3D structural model.
C-terminal: TAT-transducing domain was fused at C-terminal
Sequence
CKGKGAKCSRLMYDCCTGSCRSGKCGGGYGRKKRRQRRR
Physicochemical Analysis
C172H302N70O49S7
NEHIFPWV
RG
4359.15
10.85
14
1
5
+13
10.56
-1.354
12.56
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3355
76.96
13
Residue Composition
number
1
A
8
R
0
N
1
D
6
C
0
E
1
Q
8
G
0
H
0
I
1
L
6
K
1
M
0
F
0
P
3
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 8 H: 0 I: 0 L: 1 K: 6 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
39
C172H302N70O49S7
4359.15
10.85
+13
10.56
-1.354
TAT-transducing domain was fused at C-terminal
Linear
Similarity
Cationic
CysLysGlyLysGlyAlaLysCysSerArgLeuMetTyrAspCysCysThrGlySerCysArgSerGlyLysCysGlyGlyGlyTyrGlyArgLysLysArgArgGlnArgArgArg
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.345 micromolar

Target

HEK293 cells

Assay & Model

Acetic Acid-Induced WRITHING test
Inhibitory activity toward N-type calcium channels, albeit with a slightly reduced endothelialcacy i
Origin/Source
Tremor Symptom Test
It induces tremor symptoms
MIC

Source & Reference

NA
B3Pdb

Other

Intranasal and Intervenous
It showed that C-terminal fusion with TAT peptide render its BBB penetration capacity, without signi
Receptor-mediated transcytosis
Combined with TAT protein
Additional Detail Fields 1 fields
Intranasal and Intervenous