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Peptide record

TPDB64929

IL4rPs AP1 Blood-Brain Barrier Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB64929
IL4rPs AP1
Blood-Brain Barrier Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Blood-Brain Barrier and Tumor-homing Peptides) peptide sequence curated from BBPpredict and TumorHoPe2.0, with an available 3D structural model.
Sequence
CRKRLDRNC
Physicochemical Analysis
C44H82N20O13S2
AEQGHIMFPSTWYV
R
1163.38
10.11
4
1
1
+3
4.03
-1.733
43.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
10.74
3
Residue Composition
number
0
A
3
R
1
N
1
D
2
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C44H82N20O13S2
1163.38
10.11
+3
4.03
-1.733
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Pancreatic cancer
Interleukin-4 Receptor(IL4R)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Designed ferritin nanocages displaying trimeric TRAIL and tumor-targeting peptides confer superior anti-tumor efficacy
2020
Yoo JD et al.Sci Rep. 2020 10: 19997

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human breast adenocarcinoma MDA-MB-231 cells, Human lung cancer cell A549, Human PDAC cell line BxPC-3
5 weeks old Female or male BALB/c nude mice, 8weeks old BALB/c wild type mice
Phage Display Library
Tumor Necrosis Factor [TNF]-related apoptosis-inducing ligand(TRAIL)-ANTC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Vascular Endothelial cell
Homing
Brain tumor
Interleukin-4 Receptor(IL4R)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Application of dual targeting drug delivery system for the improvement of anti-glioma efficacy of doxorubicin
2017
Sun Z et al. Oncotarget. 2017 Aug 29 8(35): 58823–58834

Other

C6 Glioma cell line
Brain Tumor bearing Nude mice
Phage Display Library
Doxorubicin
Additional Detail Fields 3 fields
Tumor Necrosis Factor [TNF]-related apoptosis-inducing ligand(TRAIL)-ANTC Doxorubicin
Human breast adenocarcinoma MDA-MB-231 cells, Human lung cancer cell A549, Human PDAC cell line BxPC-3 C6 Glioma cell line
5 weeks old Female or male BALB/c nude mice, 8weeks old BALB/c wild type mice Brain Tumor bearing Nude mice