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Peptide record

TPDB64880

T2 Blood-Brain Barrier Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64880
T2
Blood-Brain Barrier Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict Peptipedia TumorHoPe2.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Tumor-homing Peptides) peptide sequence curated from BBPpredict, Peptipedia, and TumorHoPe2.0, with an available 3D structural model.
Sequence
SGVYKVAYDWQH
Physicochemical Analysis
C68H93N17O19
RNCEILMFPT
YV
1452.59
7.69
2
1
6
+0
0.14
-0.717
56.67
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8480
583.79
4
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
1
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
0
P
1
S
0
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 2 V: 2
Chemical Descriptors
12
C68H93N17O19
1452.59
7.69
+0
0.14
-0.717
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Hepatocarcinoma-1, Lung adenocarcinoma, B16 Melanoma, Krebs-2 carcinoma, Lewis Lung carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
Selection of antitumor displayed peptides for the specific delivery of the anticancer drug lactaptin
2016
Anna Andreevna Nemudraya et al. Oncol Lett. 2016 Dec 12(6):4547-4555.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
The hepatocarcinoma-1(HA-1), hepatocarcinoma-29(HA-29), lung adenocarcinoma (LA), Krebs-2 carcinoma, Lewis lung carcinoma, Ehrlich carcinoma strains, The В16 melanoma, human breast adenocarcinoma MDA-MB-231, MCF-7 cell line
3-4-month-old A/Sn, C57Bl/6, CBA, C3H strain mice (22-25 g)
Phage display library
RL2 (recombinant lactaptin analog), Cy5 (fluorescent dye)
Additional Detail Fields 3 fields
RL2 (recombinant lactaptin analog), Cy5 (fluorescent dye)
The hepatocarcinoma-1(HA-1), hepatocarcinoma-29(HA-29), lung adenocarcinoma (LA), Krebs-2 carcinoma, Lewis lung carcinoma, Ehrlich carcinoma strains, The В16 melanoma, human breast adenocarcinoma MDA-MB-231, MCF-7 cell line
3-4-month-old A/Sn, C57Bl/6, CBA, C3H strain mice (22-25 g)