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Peptide record

TPDB64863

cRD2D3 RD2D3 Blood-Brain Barrier standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB64863
cRD2D3 RD2D3
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 24-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
PTLHTHNRRRRRRPRTRLHTHRNR
Physicochemical Analysis
C130H226N64O31
ADCEQGIKMFSWYV
R
3181.63
13.35
14
0
2
+10
13.12
-2.633
32.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
6
Residue Composition
number
0
A
10
R
2
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
2
L
0
K
0
M
0
F
2
P
0
S
4
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 4 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C130H226N64O31
3181.63
13.35
+10
13.12
-2.633
Linear
Similarity
Pro-Thr-Leu-His-Thr-His-Asn-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Arg-Thr-Arg-Leu-His-Thr-His-Arg-Asn-Arg
Evidence Records 7 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.6

Assay & Model

Origin/Source
Brain to plasma ratio

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.3 µL/(g x min)

Assay & Model

Origin/Source
Peak response

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.0003 ml/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.0512 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 5 Activity

Activity

Blood-Brain Barrier
2 µL/(g x min)

Assay & Model

Origin/Source
Peak response

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.002 ml/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Evidence 7 Activity

Activity

Blood-Brain Barrier
0.1955 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Permeability
H3/C14
Additional Detail Fields 1 fields
Intravenous