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Peptide record

TPDB64857

ASA-ApoEI Blood-Brain Barrier standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64857
ASA-ApoEI
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 23-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugated with ASA drug
Sequence
TEELRVRLASHLRKLRKRLLRDA
Physicochemical Analysis
C122H221N45O32
NCQGIMFPWY
RL
2830.38
12.12
9
3
9
+5
9.71
-0.843
123.04
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
6
R
0
N
1
D
0
C
2
E
0
Q
0
G
1
H
0
I
6
L
2
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 6 K: 2 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C122H221N45O32
2830.38
12.12
+5
9.71
-0.843
Linear
Conjugated with ASA drug
Similarity
ThrGluGluLeuArgValArgLeuAlaSerHisLeuArgLysLeuArgLysArgLeuLeuArgAspAla
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

CHO cell line

Assay & Model

2.5 microgram/ ml
cellular uptake assay
93 % cellular uptake
Origin/Source
Lysosomal disorder

Source & Reference

NA
B3Pdb

Other

Transendocytosis
Evidence 2 Activity

Activity

Blood-Brain Barrier

Target

bEND cell line

Assay & Model

2.5 microgram/ ml
cellular uptake assay
21.2 % cellular uptake
Origin/Source
Lysosomal disorder

Source & Reference

NA
B3Pdb

Other

Transendocytosis
Evidence 3 Activity

Activity

Blood-Brain Barrier

Target

PBCECs cell line

Assay & Model

0.02% cells were added
Basolateral screening assay
200% transfer
Origin/Source
Lysosomal disorder

Source & Reference

NA
B3Pdb

Other

Basolateral