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Peptide record

TPDB64842

Angiopep-7 Blood-Brain Barrier standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB64842
Angiopep-7
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 19-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
TFFYGGSRGRRNNFRTEEY
Physicochemical Analysis
C104H149N33O31
ADCQHILKMPWV
R
2357.53
10.24
4
2
5
+2
3.29
-1.558
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
2980
126.40
7
Residue Composition
number
0
A
4
R
2
N
0
D
0
C
2
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
3
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 3 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
19
C104H149N33O31
2357.53
10.24
+2
3.29
-1.558
Linear
Similarity
Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Arg-Arg-Asn-Asn-Phe-Arg-Thr-Glu-Glu-Tyr
Evidence Records 10 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
55%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
45%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
66.67%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
33.33%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.0366 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(parenchyma/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.0183 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(capillary/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
0.061 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(brain/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
0.054 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(brain/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
0.024 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(capillary/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
0.03 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(parenchyma/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination