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Peptide record

TPDB64837

Phe13 Tyr19-Melanin Blood-Brain Barrier standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB64837
Phe13 Tyr19-Melanin
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 19-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Chemical: Cys7-Cys16
Sequence
DFDMLRCMLGRVFRPCWQY
Physicochemical Analysis
C109H162N30O26S4
ANEHIKST
R
2436.91
8.28
3
2
9
+1
-1.11
-0.105
56.32
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7115
291.97
4
Residue Composition
number
0
A
3
R
0
N
2
D
2
C
0
E
1
Q
1
G
0
H
0
I
2
L
0
K
2
M
2
F
1
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 0 M: 2 F: 2 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
19
C109H162N30O26S4
2436.91
8.28
+1
-1.11
-0.105
Cys7-Cys16
Linear
Similarity
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Phe-Arg-Pro-Cys-Trp-Gln-Tyr
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
Evidence Records 10 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000052 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

mouse,rat
Intravenous
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0153 ml/g

Assay & Model

Origin/Source
Initial distribution volume

Source & Reference

NA
B3Pdb

Other

mouse,rat
Intravenous
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00137 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

mouse,rat
in situ brain perfusion
Permeability
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.000594 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

mouse,rat
in situ brain perfusion
Permeability
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
20%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
80%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
53.3 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
78.7 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
83.3 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Evidence 10 Activity

Activity

Blood-Brain Barrier
-1.04

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

mouse,rat
Direct iodination
Additional Detail Fields 1 fields
Intravenous in situ brain perfusion