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Peptide record

TPDB64836

Ang-2 Blood-Brain Barrier standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB64836
Ang-2
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 19-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
Sequence
CTFFYGGSRGKRNNFKTEE
Physicochemical Analysis
C98H145N29O30S1
ADQHILMPWV
GF
2241.47
9.68
4
2
4
+2
4.35
-1.295
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
66.47
7
Residue Composition
number
0
A
2
R
2
N
0
D
1
C
2
E
0
Q
3
G
0
H
0
I
0
L
2
K
0
M
3
F
0
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 1 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 3 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
19
C98H145N29O30S1
2241.47
9.68
+2
4.35
-1.295
Linear
Similarity
CysThrPhePheTyrGlyGlySerArgGlyLysArgAsnAsnPheLysThrGluGlu
N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
1 mg/mL
Fluorescent microscopy
Localization of the nanoparticle within the brain cells, highlighting in particular the neuron accum

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intraperitoneal
Brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus
Transcytosis
Conjugated to poly(lactic-co-glycolic acid) (PLGA)
Additional Detail Fields 1 fields
Intraperitoneal