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Peptide record

TPDB64826

PPII(R8K) Blood-Brain Barrier standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB64826
PPII(R8K)
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia
standard
No
A 18-aa standard natural blood-brain barrier peptide sequence curated from B3Pred, BBPpredict, and Peptipedia, with an available 3D structural model.
N-terminal: Amide conjugated at N-terminus
Sequence
VRLPPPVKLPPPVRLPPP
Physicochemical Analysis
C96H161N25O19
ANDCEQGHIMFSTWY
P
1969.49
12.41
3
0
6
+3
5.19
-0.183
113.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
1
K
0
M
0
F
9
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 1 M: 0 F: 0 P: 9 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
18
C96H161N25O19
1969.49
12.41
+3
5.19
-0.183
Linear
Amide conjugated at N-terminus
Similarity
ValArgLeuProProProValLysLeuProProProValArgLeuProProPro
N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEnd.3 cells

Assay & Model

Immunofluorescence microscopy
It shows the permeability towards the BBB.
Origin/Source

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
Combined